Introduction: skin neoplasms in canines are the most frequent tumors in the veterinary clinic, being mastocytoma the most common skin cancer of this species, representing 14 – 21 % of all skin tumors diagnosed in dogs, and it is a neoplasm caused by mast cells. Objective: details of a  clinical case of cutaneous mastocytoma of high degree disseminated in the city of Cuenca in the Province of Azuay, in a patient of canine species, Yorkshire Terrier breed, 6 years old, uncastrated of 2.3kg of weight, which comes to consultation to the veterinary clinic "Patas" of the city of Cuenca for presenting intense pruritus,  ulcers, erythematous areas and firm nodules of approximately 2 cm by 2 cm with an approximate evolution time of 2 weeks, nodules found in the nose, nose, eyelids, flanks, foreskin, foreskin and hind limbs.  Methodology: this research is documentary and descriptive, for which a methodology was established for collecting chronological data from the case study of high-grade cutaneous astocytoma disseminated in a canine, with laboratory tests and medical reports. Results: performed a biopsy, obtaining as a result in the histopathological study a presumptive diagnosis of high-grade mastocytoma, subsequently performed the special Toluidin Blue stain for the differential diagnosis of cutaneous lymphoma and cutaneous reactive histiocytosis, a test that confirmed the diagnosis of a case of high-grade cutaneous mastocytoma. Conclusions: it is important to reach the definitive diagnosis through special tests such as immunohistochemistry or special stains such as toluidine blue, an important part of the treatments is oncological surgery which was limited by the dissemination at the integumentary level of the patient.

Introduction: A recent outbreak of disease worldwide about cases of acute hepatitis of unknown origin in pediatric patients has activated health alerts since in most countries an unusual increase in this disease has been reported, which has captured the attention, due to rapid progress towards acute liver failure. Objective: Describe the relationship between human adenovirus infection and hepatitis of unknown origin in pediatrics. Methodology: A bibliographic review was conducted on human adenovirus infection as a potential cause of hepatitis in pediatrics, for which several studies published in databases such as PubMed, SciELO, Scopus, and Web of Science were used. Results: The causality of this disease remains uncertain up to now, but several hypotheses have been proposed, among them the most accepted allegation that it could be a consequence of infection by human adenovirus and although it is well established that infections by this pathogen are common in children, the severity of clinical symptoms as the underlying cause is not fully justified. Conclusion: It will be a challenge to determine the role of adenovirus in acute pediatric hepatitis, since understanding its pathophysiology will allow developing effective surveillance and treatment strategies that prevent exacerbation of the disease and liver transplantation. Meanwhile, it is suggested to consider adenovirus as the differential diagnosis of acute non-A-E hepatitis.

Introduction. Computer Vision Syndrome (CVS) is a disorder that often affects individuals who frequently use electronic devices, causing symptoms that not only affect the visual and ocular system, but can also cause discomfort at the musculoskeletal level. During the transition from in-person to virtual education due to the COVID-19 pandemic, teachers significantly increased their time spent on teleworking and virtual teaching, leading to an increased incidence of CVS and symptoms affecting their comfort during and after work hours. Objective. The objective was to identify the symptoms of CVS in teachers and the strategies they have used to reduce them. Methodology. A qualitative methodology was employed using narrative design, consisting of in-depth interviews to explore the symptoms of CVS and the strategies used by affected teachers. Then, preventive material was designed and evaluated by the teachers in question. Results. Teachers presented symptoms related to CVS that affected their comfort during and after work hours. The symptoms included visual fatigue, headache, eye, and cervical irritation, and in some cases, psychosocial symptoms such as anxiety and stress. Teachers implemented various strategies, such as using eye lubricants, taking active breaks, and adopting optimal ergonomic positions in front of screens. The preventive material designed was positively evaluated by teachers. Conclusion. CVS is a frequent problem in teachers working in a virtual and teleworking mode. Implementation of strategies and availability of preventive material can reduce the symptoms related to CVS.

Introduction: The application of the flipped classroom in language and literature learning is very important because there is interaction and engagement of everyone in the classroom. The research analyzes factors such as students' collaborative learning, as well as the capacity of language and literature practice. Objective. The present research consists of the elaboration of an investigation that deals with the inverted classroom based on the learning of language and literature. Methodology. It identifies the relevant literature, evaluates the selected studies, analyzes the data and synthesis of the information, interprets the findings, and finally presents the findings and conclusions of the review in a clear and precise manner, using appropriate citations and bibliographical references to support the arguments presented. Results. Obtaining results on the feasibility and effectiveness to improve students' interest in learning. It is found that when technologies are adapted to the classroom, the results are favorable, as well as the students' interest is increased. Likewise, it is identified that all the contents shared in the classroom are suitable for the inverted classroom technique, so the teacher must have the ability to select those topics that really contribute significantly to this technique of collaborative work in the classroom. Conclusion. The flipped classroom has the potential to revolutionize education by promoting student-centered learning and empowering students to take control of their own education. It has proven to be an effective approach to language and literacy learning. General area of study: Education. Specific area of study: Collaborative education.

Introduction: Myelomeningocele is the most common neural tube defect; one case per one thousand live births is reported. It is more frequent in females, resulting in disabling sequelae, including urological sequelae. They can be corrected with different surgical techniques and complex urological derivations that predispose them to repeated urinary tract infections and, when there is pregnancy, maternal-fetal complications, and difficulty for surgical access, in case of cesarean section. Clinical case: Patient 14 weeks pregnant, 27 years old, diagnosed with myeloma ningocele and vesicoplasty, with multiple urinary tract infections and preterm rupture of membranes. Termination of pregnancy by cesarean section at 33 weeks, due to fetal conditions. The cesarean section technique was modified so as not to damage the cystoplasty and to avoid complications with adhesions in the pelvis. Conclusions: The best maternal-fetal prognosis in patients with complex urologic diversion is achieved with the intentional search for urinary tract infections and timely and adequate treatment, in addition to multidisciplinary planning at the time of termination of pregnancy.

Introduction: Metacognitive learning strategies become a key element that allows the student to orient himself in the information available through his organization, through which he develops mathematical logical reasoning abilities. Objective: to analyze the way in which metacognitive strategies contribute to logical reasoning and mathematical problem solving in students of the Mathematics and Physics Pedagogy Career at the Luis Vargas Torres de Esmeraldas Technical University. Methodology: paradigm centered on positivism, involving a quantitative, analytical, rationalist, scientific and technological systematic approach; applying as technique the survey to forty students belonging to the university mentioned above. Results: 38% of the students stated that they rarely imagine the problem to decide how to solve it, evidencing the mechanical learning they have in reference to solving mathematical problems. Conclusion: metacognitive strategies significantly influence logical reasoning, therefore, in solving mathematical problems, a teaching should be proposed in which didactic strategies and various methodologies related to metacognitive strategies are used that will allow students to control and monitor the use of their cognitive resources, resulting from planning, verification, monitoring, review and evaluation of their cognitive achievements.

Introduction: Cancer is a very frequent pathology globally, among the most complicated types are neoplasms of hematological origin. The established treatments for them revolve around chemotherapy or hematopoietic stem cell transplantation, however, it has been shown that these are not effective in all patients, in addition to a high percentage of relapses after their use. Objective: To describe the characteristics of chimeric antigen receptor T-cell therapy as a new treatment alternative in hematological malignancies. Methodology: A bibliographic review was conducted on chimeric antigen receptor T-cell immunotherapy in hematological malignancies. In databases such as PubMed, Scopus and Dialnet. For the extraction of data, articles that expose the characteristics, usefulness, and new advances of CAR T cell therapy in hematological malignancies were prioritized Results: Chimeric antigen receptor (CAR) T-cell immunotherapy is evidenced as a promising option in patients with hematological malignancies, due to its high rate of effectiveness, positioning itself as a new therapeutic choice, providing a broader vision in the hematological field. It has been approved as a treatment for acute myeloid leukemia or B-cell lymphoma. Conclusion: The combination of this therapy together with other cytokine inhibitors would be an excellent choice in the future. Even though effective results have been obtained in different studies, it can also be shown that in some cases the participants presented adverse effects to CAR T cell immunotherapy, for which reason the mechanisms involved in complications continue to be studied in order to generate strategies that increase the effectiveness of treatment and reduce complications

Introduction: The increase in infectious hospital waste, since the arrival of COVID-19 in the country, led to the conducting of this study. Objectives: Theoretically describe the management by processes of hazardous and non-hazardous solid waste in the hospital environment. Methodology: bibliographic review, to expose through the tools of management by processes, complemented with the model of continuous improvement, the optimization of the management of hazardous and common waste, in health establishments. Results: The main result obtained showed that, through the application of the administrative tools, the efficiency of the tasks of classification, collection, storage, transport, and final disposal of hospital waste is strengthened, promoting a permanent improvement of the same. Conclusions: Process management contributed to the optimal management of hazardous and non-hazardous solid waste in the hospital environment, for the benefit of the community and preservation of natural resources. General study area: Industrial Engineering. Specific study area: Environmental Management.

Introduction: Smoking is the main individual cause of preventable deaths in the world, so currently, due to the damage associated with tobacco, new alternatives to traditional cigarettes have been incorporated, such as electronic cigarettes; however, due to the consumption of these, there are new reports about the syndrome of lung injury associated with the use of electronic cigarettes or vaping products (EVALI) so this review seeks to detail which are these injuries that occur and compare them with the injuries of traditional cigarette consumption. Objective: The objective of the present investigation has been to carry out a review of the bibliography about the pathological characteristics that can be presented by the consumption of these devices. Methodology: A narrative bibliographic review was carried out about acute lung damage in the lung parenchyma associated with traditional cigarette consumption vs. electronic cigarette performing a search in different databases such as pubmed, scopus, elsevier. Development: It is thought that vitamin E acetate may be one of the substances found in electronic cigarette liquid that has the greatest association with EVALI; in turn, the sweeteners and flavorings used in these preparations increase the probability that people try or continue to use e-cigarette products facilitating the use of nicotine in these devices by masking the aversive properties of nicotine. Regarding the acute lesions found by traditional cigarettes, acute eosinophilic pneumonia was detailed, which, when compared with the pathological findings caused by EVALI, similarities such as type II pneumocyte hyperplasia, increased amount of intra-alveolar fibrin, and eosinophilic infiltration were observed. Conclusion: Both electronic and traditional cigarettes can present acute pathologies, differentiating them into acute eosinophilic pneumonia and EVALI, so the switch to electronic cigarettes does not present any benefit for the consumer. General area of study: Medicine. Specific area of study: Pneumology, Pathology.

Introduction. The present systematic review is associated with the levels of depression, anxiety and its relationship with the academic performance of university students in the health area. Objective. The main objective of this research is focused on determining the levels of depression, anxiety and their relationship with the academic performance of university students in the health area from a systematic review. Methodology. It is a study of secondary origin of a systematic type without meta-analysis in which PRISMA-type methodology was used to search the literature. For the development of the systematic review, the following scientific databases were selected: Scielo, Pubmed, Redalyc and Proquest. The search strategies focused on the identification of MeSH terms, which correspond to: "anxiety", "depression", "Academic Performance" and "Health students". Results. Among the main results obtained from the search, a total of 9 studies were identified in the Scielo database, 725 in the Pubmed database, 6276 in the Redalyc database, and 7241 in Proquest. Finally, it was established that the included studies correspond to cross-sectional, descriptive, and correlational studies, with a total of 9266 students from the various branches of health. Conclusion. The results obtained allowed us to establish that there is a direct relationship between the level of stress and/or depression and the low performance of the students. However, it is necessary to continue conducting research to investigate other intervening variables that may or may not have a direct correlation with the academic performance of students in health-related careers.